[8] Santa Clara 1-0 Rio Ave [15] 2021-05-11 15:00
stadio: Estadio de Sao Miguel Round: 32
Arbitro: Hugo Miguel Home Manager: Daniel Ramos Away Manager: Miguel Cardoso
Head to Head
| Portogallo - Primeira Liga | 2021/01/25 16:30 | Rio Ave v Santa Clara | W | 1-2 |
| Portogallo - Primeira Liga | 2020/07/18 18:00 | Rio Ave v Santa Clara | D | 2-2 |
| Portogallo - Primeira Liga | 2020/01/10 19:00 | Santa Clara v Rio Ave | L | 0-1 |
| Amichevoli Europa | 2019/07/20 17:30 | Rio Ave v Santa Clara | D | 1-1 |
| Portogallo - Primeira Liga | 2019/02/15 20:30 | Rio Ave v Santa Clara | W | 1-2 |
| Portogallo - Primeira Liga | 2018/09/22 15:30 | Santa Clara v Rio Ave | L | 1-3 |
| Coppa del Portogallo | 2016/10/16 11:00 | Santa Clara v Rio Ave | W | 5-3 |